Hellenic Academy of Neuroimmunology
 
  • THE ACADEMY
    • MISSION STATEMENT
    • GENERAL ASSEMBLY MEMBERS
    • EXECUTIVE COMMITTEE MEMBERS
    • SCIENTIFIC COMMITTEES
    • GRANT COMMITTEE
    • LEGAL REPRESENTATION
  • HELANI CONGRESSES
    • 1st HELANI PANHELLENIC CONGRESS
    • 2nd HELANI PANHELLENIC CONGRESS
    • 3rd HELANI PANHELLENIC CONGRESS
    • 4th HELANI PANHELLENIC CONGRESS
    • 5th HELANI PANHELLENIC CONGRESS
    • 6th HELANI PANHELLENIC CONGRESS
    • 7th HELANI PANHELLENIC CONGRESS
    • 8th HELANI PANHELLENIC CONGRESS
    • 9th HELANI PANHELLENIC CONGRESS
  • EDUCATION AND RESEARCH
    • THE FIELD OF NEUROIMMUNOLOGY
  • BRAIN PROTECTION
    • MULTIPLE SCLEORSIS - GENERAL
    • BRAIN VOLUME
    • MULTIPLE SCLEROSIS - COGNITIVE FUNCTION
    • NEDA CRITERIA
  • MEMBERS OF HELANI
  • ANNOUNCEMENTS - NEWS
  • CONTACT

Cognitive function in Multiple Sclerosis.


Cognitive impairment occurs in 45-65% of multiple sclerosis patients. Cognitive decline is mild in 80% of cases and is more obvious in the secondary progressive form of the disease; however some patients may present predominant cognitive impairment without severe physical disability. Cognitive impairment typically involves attention, information processing speed and memory.

Cognitive impairment in multiple sclerosis correlates strongly with the rate of brain volume loss; the latter is greater in most of the untreated patients compared to the healthy individuals. Studies with functional magnetic resonance imaging have shown that in the early stages of the disease, cortical reorganization provides compensation for cognitive deficits. Cognitive reserve is a protective factor against cognitive decline. Intellectual enrichment can also provide compensation for cognitive deficits, thus recent research aims to the potential benefits of cognitive rehabilitation.
 
References:
1. Langdon D cognition in multiple sclerosis Curr Op Neur 2011 , 24:244-249.
2. Zivadinov R,S epcic J et al,A longitudinal study of brain atrophy and cognitive disturbances in the early phase of relapsing-remitting multiple sclerosis ,JNNP 2001, 70(6)773-880.
3. Schoonheim MM, Geurts JJ et al The limits of functional reorganization in multiple sclerosis , Neurology 2010 74(16)1246-1247.
4. Sumowski, James F. et al. “Brain Reserve and Cognitive Reserve in Multiple Sclerosis: What You’ve Got and How You Use It.” Neurology 80.24 (2013): 2186–2193. PMC. Web. 21 Oct. 2015.
5. Sumowski, James F. et al. “Brain Reserve and Cognitive Reserve Protect against Cognitive Decline over 4.5 Years in MS.” Neurology 82.20 (2014): 1776–1783. PMC. Web. 21 Oct. 2015.


Terms of use

Copyright © 2015